Feng Zhang (张锋), Ph.D.

ZF1Professor, School of Life Sciences, Fudan University
PI, State Key Laboratory of Genetic Engineering & Ministry of Education Key Laboratory of Contemporary Anthropology

Research Interests

Human genomic rearrangements; copy number variations (CNVs)/structural variations (SVs) and their roles in human diseases and genome evolution

Education and Experience

  • Professor/PI, Fudan University, China, 2011-present
  • Associate Investigator, Fudan University, China, 2009-2011
  • Postdoctoral Associate, Baylor College of Medicine, USA, 2007-2009
  • Ph.D. in Genetics, Fudan University, China, 2007
  • B.E. in Biochemical Engineering, East China University of Science and Technology (ECUST), China, 2002

Honors

  • Shanghai Shu Guang Scholar, Education Commission of Shanghai Municipality, 2012
  • Excellent Young Scholar, National Natural Science Foundation of China, 2012
  • Shanghai Science and Technology Award, Shanghai Municipality, 2012
  • Shanghai Medical Science and Technology Award, Shanghai Medical Association, 2011
  • Shanghai Pujiang Scholar, Science and Technology Commission of Shanghai Municipality, 2010
  • New Century Excellent Talents in University, Ministry of Education of China, 2009

Selected Publications

Zhou W*,Zhang F*,#, Chen X, Shen Y, Lupski JR, Jin L (2013) Increased genome instability in human DNA segments with self chains: homology-induced structural variations via replicative mechanisms.Human Molecular Genetics (in press)

Sun Z, Liu P, Jia X, Withers MA, Jin L, Lupski JR, Zhang F# (2013) Replicative mechanisms of CNV formation preferentially occur as intrachromosomal events: evidence from Potocki-Lupski duplication syndrome. Human Molecular Genetics 22(4):749-756.

Du R, Lu C, Jiang Z, Li S, Ma R, An H, Xu M, An Y, Xia Y, Jin L, Wang X, Zhang F# (2012) Efficient typing of copy number variations in a segmental duplication-mediated rearrangement hotspot using multiplex competitive amplification. Journal of Human Genetics 57:545-551.

Fu W, Zhang F, Wang Y, Gu X, Jin L (2010) Identification of copy number variation hotspots in human populations. American Journal of Human Genetics 87(4):494-504.

Zhang F, Seeman P, Liu P, Weterman MA, Gonzaga-Jauregui C, Towne CF, Batish SD, De Vriendt E, De Jonghe P, Rautenstrauss B, Krause KH, Khajavi M, Posadka J, Vandenberghe A, Palau F, Van Maldergem L, Baas F, Timmerman V, Lupski JR (2010) Mechanisms for nonrecurrent genomic rearrangements associated with CMT1A or HNPP: Rare CNVs as a cause for missing heritability. American Journal of Human Genetics 86(6):892-903.

Zhang F, Potocki L, Sampson JB, Liu P, Sanchez-Valle A, Robbins-Furman P, Navarro AD, Wheeler PG, Spence JE, Brasington CK, Withers MA, Lupski JR (2010) Identification of uncommon recurrent Potocki-Lupski syndrome-associated duplications and the distribution of rearrangement types and mechanisms in PTLS. American Journal of Human Genetics 86(3):462-470.

Zhang F, Gu W, Hurles ME, Lupski JR (2009) Copy number variation in human health, disease, and evolution. Annual Review of Genomics and Human Genetics 10:451-481.

Zhang F, Carvalho CM, Lupski JR (2009) Complex human chromosomal and genomic rearrangements. Trends in Genetics 25(7):298-307.

Zhang F, Khajavi M, Connolly AM, Towne CF, Batish SD, Lupski JR (2009) The DNA replication FoSTeS/MMBIR mechanism can generate human genomic, genic, and exonic complex rearrangements. Nature Genetics 41(7):849-853.

Zhang F*, Lu C*, Li Z, Xie P, Xia Y, Zhu X, Wu B, Cai X, Wang X, Qian J, Wang X, Jin L (2007) Partial deletions are associated with an increased risk of complete deletion in AZFc: A new insight into the role of partial AZFc deletions in male infertility. Journal of Medical Genetics 44(7):437-444.

Professional Organizations

Member, American Society of Human Genetics
Member, European Society of Human Genetics
Member, Human Genome Organisation
Member, Young Committee, Medical Genetics Society of Chinese Medical Association