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In June

In June REN Luyao will become a graduate student of School of Life Sciences,Fudan University. Wish her an academic success and a smooth life of scientific research. Our graduate student ZHANG Xue, who now is a clinical research specialistat Medtronic Inc. Wish her a happy work. Dr.CHEN Lu will go to the...

Welcome

Welcome Professor Yanhua Wu and her team. We all believe the new collaborations will be fruitfill.

TBX6 Null Variants and a Common Hypomorphic Allele in Congenital Scoliosis

N Engl J Med. 2015 Jan 22;372(4):341-50. Background: Congenital scoliosis is a common type of vertebral malformation. Genetic susceptibility has been implicated in congenital scoliosis. Methods: We evaluated 161 Han Chinese persons with sporadic congenital scoliosis, 166 Han Chinese controls, and 2...

Journal Club-Genome editing with RNA guided Cas9 nuclease in Zebrafish embryos

This is an original article published in early 2013 in Cell Research magazine. It mainly includes four parts of experiments: Cas9/gRNA ribonucleoprotein complex executes site-specific DNA cleavage in mammalian cells; Cas9/gRNA induces indels in the etsrp locus in zebrafish; Cas9/gRNA induces indels in...

Increased genome instability in human DNA segments with self-chains: homology-induced structural variations via replicative mechanisms

Hum. Mol. Genet. (2013) 22 (13): 2642-2651. Environmental factors including ionizing radiation and chemical agents have been known to be able to induce DNA rearrangements and cause genomic structural variations (SVs); however, the roles of intrinsic characteristics of the human genome, such as regional...

Replicative mechanisms in PTLS syndrome

Human Molecular Genetics, 2013, Vol. 22, No. 4 749–756 Copy number variations (CNVs) in the human genome contribute significantly to disease. De novo CNV mutations arise via genomic rearrangements, which can occur in ‘trans’, i.e. via interchromosomal events, or in ‘cis’, i.e. via...

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