Welcome

Welcome

The Genomic Disorders Group was created in 2009 at State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China. Our researches mainly focus on human genomic rearrangements and large-scale DNA mutations, such as copy number variations (CNVs) and structural variations (SVs). We are asking: To what extent are CNVs/SVs responsible for human Mendelian and complex diseases? What are the molecular mechanisms for human CNV/SV formation? What roles did CNVs/SVs play in human population...
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Posted by on Jul 26, 2016 | 0 comments

In June

In June REN Luyao will become a graduate student of School of Life Sciences,Fudan University. Wish her an academic success and a smooth life of scientific research. Our graduate student ZHANG Xue, who now is a clinical research specialistat Medtronic Inc. Wish her a happy work. Dr.CHEN Lu will go to the United States for postdoctoral training.
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Posted by on Jul 26, 2016 | 0 comments

Welcome

Welcome Professor Yanhua Wu and her team. We all believe the new collaborations will be fruitfill.
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Posted by on Jan 11, 2015 | 0 comments

TBX6 Null Variant...

N Engl J Med. 2015 Jan 22;372(4):341-50. Background: Congenital scoliosis is a common type of vertebral malformation. Genetic susceptibility has been implicated in congenital scoliosis. Methods: We evaluated 161 Han Chinese persons with sporadic congenital scoliosis, 166 Han Chinese controls, and 2 pedigrees, family members of which had a 16p11.2 deletion, using comparative genomic hybridization,...
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Posted by on Jun 9, 2014 | 0 comments

Journal Club-Genome editin...

This is an original article published in early 2013 in Cell Research magazine. It mainly includes four parts of experiments: Cas9/gRNA ribonucleoprotein complex executes site-specific DNA cleavage in mammalian cells; Cas9/gRNA induces indels in the etsrp locus in zebrafish; Cas9/gRNA induces indels in the gata4and gata5 loci in zebrafish; Cas9/gRNA induces insertion of mloxP at the break...
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Posted by on Jun 17, 2013 | 0 comments

Increased genome instabili...

Increased genome instability in human DNA segments with self-chains: homology-induced structural variations via replicative mechanisms
Hum. Mol. Genet. (2013) 22 (13): 2642-2651. Environmental factors including ionizing radiation and chemical agents have been known to be able to induce DNA rearrangements and cause genomic structural variations (SVs); however, the roles of intrinsic characteristics of the human genome, such as regional genome architecture, in SV formation and the potential mechanisms underlying genomic instability remain...
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Posted by on Mar 20, 2013 | 0 comments

Replicative mechanisms in ...

Replicative mechanisms in PTLS syndrome
Human Molecular Genetics, 2013, Vol. 22, No. 4 749–756 Copy number variations (CNVs) in the human genome contribute significantly to disease. De novo CNV mutations arise via genomic rearrangements, which can occur in ‘trans’, i.e. via interchromosomal events, or in ‘cis’, i.e. via intrachromosomal events. However, what molecular mechanisms occur between chromosomes versus between...
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